Jung A, Singh M M, Jajoo U
Department of Internal Medicine, Mahatma Gandhi Insttute of Medical Sciences, Sewagram, Wardha.
Indian J Med Sci. 1999 Dec;53(12):535-44.
A study was conducted to analyse the causes of fever of unknown origin (FUO) in a teaching hospital in central India. Study subjects consisted of 233 patients having FUO admitted in the medical ward. Specific causes of FUO were identified in 73.4% cases. The commonest causes (46.4%) were of infectious diseases origin foremost being enteric fever (29.6%) followed by malaria (9.0%) and tuberculous fever (5.2%). Chloroquine responsive fever accounted for 26% cases of FUO. Enteric fever were seen more commonly in younger adults less than 50 years, tuberculous fever presented usually after four weeks of onset of symptoms and more in elderly patients aged 50 years or more. Intermittent type of fever was more commonly recorded in infectious diseases. Approach to causes of FUO should be focused primarily on infectious diseases followed by other specific investigations. Empirical treatment of cases having intermittent fever with chloroquine seems justifiable even in absence of malarial parasite in peripheral blood smear.
一项研究旨在分析印度中部一家教学医院不明原因发热（FUO）的病因。研究对象包括医学病房收治的233例不明原因发热患者。73.4%的病例确定了不明原因发热的具体病因。最常见的病因（46.4%）是传染病，其中最主要的是伤寒（29.6%），其次是疟疾（9.0%）和结核热（5.2%）。氯喹反应性发热占不明原因发热病例的26%。伤寒在50岁以下的年轻人中更为常见，结核热通常在症状出现四周后出现，且在50岁及以上的老年患者中更为多见。间歇性发热在传染病中更为常见。不明原因发热病因的研究方法应主要集中在传染病上，其次是其他特定检查。即使外周血涂片未发现疟原虫，对间歇性发热病例采用氯喹进行经验性治疗似乎也是合理的。
