Hot Arnaud, Schmulewitz Laura, Viard Jean-Paul, Lortholary Olivier
Université Paris V, Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75743 Paris Cedex 15, France.
Infect Dis Clin North Am. 2007 Dec;21(4):1013-32, ix. doi: 10.1016/j.idc.2007.08.003.
Fever of unknown or uncertain origin (FUO) constitutes a common clinical challenge in patients infected with HIV. It is usually caused by disseminated opportunistic infection, and the relative frequency of each cause of FUO is influenced by multiple factors including CD4 count, geographic setting, and local prevalences of infectious agents, which may provide clues to the diagnosis. Infections presenting as FUO in the HIV population occur most often in the late stages of the disease and high diagnostic suspicion for mycobacterial disease should be maintained when evaluating these patients, particularly in areas of high prevalence. This article discusses the causes, diagnosis, and treatment of FUO in HIV-infected individuals.
不明原因或不确定来源的发热（FUO）是感染HIV患者常见的临床挑战。它通常由播散性机会性感染引起，FUO各病因的相对频率受多种因素影响，包括CD4细胞计数、地理环境以及感染病原体的当地流行率，这些因素可能为诊断提供线索。在HIV人群中表现为FUO的感染最常发生在疾病晚期，在评估这些患者时，应高度怀疑分枝杆菌病，尤其是在高流行地区。本文讨论了HIV感染个体中FUO的病因、诊断和治疗。
