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小鼠中与H-2相关的对可溶性小牛皮肤胶原蛋白抗体反应的遗传控制。

H-2-linked genetic control of antibody response to soluble calf skin collagen in mice.

作者信息

Hahn E, Nowack H, GOTZE D, Timpl R

出版信息

Eur J Immunol. 1975 Apr;5(4):288-91. doi: 10.1002/eji.1830050415.

DOI:10.1002/eji.1830050415
PMID:1086233
Abstract

An autosomal dominant immune response gene could be demonstrated in congenic resistant strains of mice which is linked to the H-2 locus and controls the antibody response to soluble calf collagen. High responsiveness was associated with the H-2 alleles, b and f, low responsiveness with the H-2 alleles, d, k, m and r. Studies with calf procollagen, which contains an additional carrier moiety, indicated that these genetic differences might be expressed at the level of T cells.

摘要

在与H-2位点连锁并控制对可溶性小牛胶原蛋白抗体反应的小鼠同基因抗性品系中，可以证明存在一个常染色体显性免疫反应基因。高反应性与H-2等位基因b和f相关，低反应性与H-2等位基因d、k、m和r相关。对含有额外载体部分的小牛前胶原蛋白的研究表明，这些基因差异可能在T细胞水平上表现出来。

相似文献

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H-2-linked genetic control of antibody response to soluble calf skin collagen in mice.小鼠中与H-2相关的对可溶性小牛皮肤胶原蛋白抗体反应的遗传控制。
Eur J Immunol. 1975 Apr;5(4):288-91. doi: 10.1002/eji.1830050415.
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引用本文的文献

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J Exp Med. 1981 Sep 1;154(3):688-700. doi: 10.1084/jem.154.3.688.
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J Exp Med. 1982 Feb 1;155(2):445-59. doi: 10.1084/jem.155.2.445.
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Am J Pathol. 1984 Oct;117(1):1-11.
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