小鼠Ⅱ型胶原诱导性关节炎。I. 主要组织相容性复合体（I区）连锁及抗体相关性
Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.
作者信息
Wooley P H, Luthra H S, Stuart J M, David C S
出版信息
J Exp Med. 1981 Sep 1;154(3):688-700. doi: 10.1084/jem.154.3.688.
Abstract
A model of arthritis was established by the injection of type II collagen into mice. Only mice bearing the H-2q haplotype were susceptible to the disease. Susceptibility was further mapped by the use of recombinant strains on the Iq locus. Type II collagen arthritis was observed in the (resistant X susceptible) F1 cross. Mice strains were designated high, intermediate, or low responders with respect to the anti-type II antibody levels measured by radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody responders. The clinical and histological appearance of type II collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis.
摘要
通过向小鼠注射II型胶原蛋白建立了关节炎模型。只有携带H-2q单倍型的小鼠易患该病。利用Iq位点上的重组菌株进一步定位了易感性。在（抗性×易感）F1杂交中观察到II型胶原蛋白关节炎。根据放射免疫测定法测得的抗II型抗体水平，将小鼠品系分为高、中、低反应者。关节炎易感品系均被归类为高抗体反应者。小鼠II型胶原蛋白关节炎的临床和组织学表现表明，它可能是研究类风湿关节炎各种免疫遗传特征的良好动物模型。
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