Nagler-Anderson C, Bober L A, Robinson M E, Siskind G W, Thorbecke G J
Proc Natl Acad Sci U S A. 1986 Oct;83(19):7443-6. doi: 10.1073/pnas.83.19.7443.
Although oral administration of protein antigens may lead to specific immunologic unresponsiveness, this method of immunoregulation has not been applied to models of autoimmune disease. Type II collagen-induced arthritis is an animal model of polyarthritis induced in susceptible mice and rats by immunization with type II collagen, a major component of cartilage. Intragastric administration of soluble type II collagen, prior to immunization with type II collagen in adjuvant, suppresses the incidence of collagen-induced arthritis. Administration of denatured type II collagen has no observable effect on the incidence or severity of the disease. The overall magnitude of the antibody response is not significantly reduced in collagen-fed mice as compared to controls. While the isotype distribution of the anti-collagen antibodies is similar in the two groups, there is a tendency toward reduced IgG2 responses in the collagen-fed mice.
虽然口服蛋白质抗原有可能导致特异性免疫无反应性，但这种免疫调节方法尚未应用于自身免疫性疾病模型。II型胶原诱导的关节炎是一种在易感小鼠和大鼠中通过用软骨的主要成分II型胶原免疫而诱发的多关节炎动物模型。在用佐剂中的II型胶原免疫之前，经胃内给予可溶性II型胶原可抑制胶原诱导的关节炎的发病率。给予变性II型胶原对疾病的发病率或严重程度没有可观察到的影响。与对照组相比，喂食胶原的小鼠中抗体反应的总体强度没有显著降低。虽然两组中抗胶原抗体的同种型分布相似，但喂食胶原的小鼠中IgG2反应有降低的趋势。
