Joloba M L, Johnson J L, Namale A, Morrissey A, Assegghai A E, Mugerwa R D, Ellner J J, Eisenach K D
Department of Medical Microbiology, Makerere University, Kampala, Uganda.
Int J Tuberc Lung Dis. 2000 Jun;4(6):528-36.
National Tuberculosis (TB) Treatment Centre, Mulago Hospital and Joint Clinical Research Centre, Kampala, Uganda.
To compare the quantitative sputum bacillary load between TB patients infected with the human immunodeficiency virus (HIV) and those non-infected, during treatment with standard short course chemotherapy (SCC).
To compare clinical characteristics and quantitative sputum bacillary load as measured by quantitative acid-fast bacilli (AFB) smears, colony forming unit (cfu) assay and time until positive culture in the BACTEC radiometric liquid system between 14 HIV-infected and 22 non-HIV-infected adults with initial episodes of smear-positive pulmonary TB at baseline and during treatment with standard four-drug SCC.
Other than cavitation (P = 0.042) and adenopathy (P = 0.03), which were more common among non-HIV-infected and HIV-infected patients, respectively, there were no significant differences in baseline demographic, clinical, radiological and laboratory characteristics between the groups. Mean pretreatment sputum bacillary burden (6.5+/-0.51 log10 AFB/ml, 5.91+/-0.91 log10 cfu/ml and 1.8+/-1.7 days until positive BACTEC culture for HIV-infected patients and 6.32+/-0.85 log10 AFB/ml, 5.58+/-0.68 log10 cfu/ml and 1+/-1.2 days until positive BACTC culture for non-HIV-infected patients) were comparable between HIV-infected and non-HIV-infected patients. Clinical and bacteriological responses to standard SCC and treatment outcome did not differ between the groups.
Quantitative sputum bacillary load at baseline and during SCC did not differ significantly between HIV-infected and non-HIV-infected adults with initial episodes of smear-positive TB.
乌干达坎帕拉穆拉戈医院国家结核病治疗中心和联合临床研究中心。
比较感染人类免疫缺陷病毒（HIV）的结核病患者与未感染HIV的结核病患者在接受标准短程化疗（SCC）期间的痰液细菌定量负荷。
比较14例HIV感染和22例未感染HIV的成人初发涂片阳性肺结核患者在基线和接受标准四联SCC治疗期间的临床特征以及通过定量抗酸杆菌（AFB）涂片、菌落形成单位（cfu）测定和BACTEC放射性液体系统中培养阳性所需时间所测得的痰液细菌定量负荷。
除空洞形成（P = 0.042）和淋巴结病（P = 0.03）分别在未感染HIV和感染HIV的患者中更常见外，两组在基线人口统计学、临床、放射学和实验室特征方面无显著差异。HIV感染患者的平均治疗前痰液细菌负荷（6.5±0.51 log10 AFB/ml、5.91±0.91 log10 cfu/ml以及BACTEC培养阳性所需1.8±1.7天）与未感染HIV患者的（6.32±0.85 log10 AFB/ml、5.58±0.68 log10 cfu/ml以及BACTEC培养阳性所需1±1.2天）相当。两组对标准SCC的临床和细菌学反应以及治疗结果无差异。
初发涂片阳性肺结核的HIV感染和未感染HIV的成人在基线和SCC治疗期间的痰液细菌定量负荷无显著差异。
