Joloba M L, Johnson J L, Namale A, Morrissey A, Assegghai A E, Rüsch-Gerdes S, Mugerwa R D, Ellner J J, Eisenach K D
Department of Medical Microbiology, Makerere University, Joint Clinical Research Centre, Kampala, Uganda.
Int J Tuberc Lung Dis. 2001 Jun;5(6):579-82.
Data regarding possible differences in microbiological response to therapy of disease caused by Mycobacterium tuberculosis and M. africanum are limited. Presenting clinical characteristics and sputum bacillary load during standard short-course chemotherapy in patients with newly-diagnosed pulmonary tuberculosis due to M. tuberculosis (n = 7) and M. africanum (n = 6) were compared. Changes in sputum bacillary load were measured using quantitative acid-fast bacilli smears, colony forming unit assay, and time until positive culture in the BACTEC radiometric system. Presentation and response to short course chemotherapy were comparable between patients infected with M. tuberculosis and those infected with M. africanum.
关于结核分枝杆菌和非洲分枝杆菌所致疾病在微生物学治疗反应方面可能存在的差异，相关数据有限。对7例由结核分枝杆菌引起的新诊断肺结核患者和6例由非洲分枝杆菌引起的新诊断肺结核患者在标准短程化疗期间的临床特征及痰菌负荷进行了比较。使用定量抗酸杆菌涂片、菌落形成单位测定法以及BACTEC放射测量系统中培养转为阳性的时间来测量痰菌负荷的变化。感染结核分枝杆菌的患者与感染非洲分枝杆菌的患者在临床表现及对短程化疗的反应方面具有可比性。
