Rabino C, Aspegren A, Corbin-Lickfett K, Bridge E
Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
J Virol. 2000 Jul;74(14):6684-8. doi: 10.1128/jvi.74.14.6684-6688.2000.
Adenovirus late mRNA export is facilitated by viral early proteins of 55 and 34 kDa. The 34-kDa protein contains a leucine-rich nuclear export signal (NES) similar to that of the human immunodeficiency virus Rev protein. It was proposed that the 34-kDa protein might facilitate the export of adenovirus late mRNA through a Rev-like NES-mediated export pathway. We have tested the role of NES-mediated RNA export during adenovirus infection, and we find that it is not essential for the expression of adenovirus late genes.
腺病毒晚期mRNA的输出由55 kDa和34 kDa的病毒早期蛋白促进。34 kDa的蛋白含有一个富含亮氨酸的核输出信号（NES），类似于人类免疫缺陷病毒Rev蛋白的核输出信号。有人提出，34 kDa的蛋白可能通过类似Rev的NES介导的输出途径促进腺病毒晚期mRNA的输出。我们测试了NES介导的RNA输出在腺病毒感染过程中的作用，发现它对于腺病毒晚期基因的表达并非必不可少。
