Fischer C L, Gill C, Forrester M G, Nakamura R
Am J Clin Pathol. 1976 Nov;66(5):840-6. doi: 10.1093/ajcp/66.5.840.
Serial determinations of serum C-reactive protein are helpful in the detection and monitoring of postoperative complications associated with inflammation and/or tissue necrosis. The serum C-reactive protein level begins to increase within sex hours after operation, peaks on the second day, and by the third postoperative day begins to decrease toward the preoperative level. In cases with surgical complications involving inflammation, serum C-reactive protein levels remain elevated and do not show a decline on the third postoperative day. Serum levels of other "acute-phase proteins," such as alpha-1 acid glycoprotein, ceruloplasmin, alpha-1 antitrypsin, and haptoglobin, were found to increase in response to surgical procedures, but subsequent to the increase in C-reactive protein. These other proteins offer no additional information in monitoring the postoperative acutephase response,
连续测定血清C反应蛋白有助于检测和监测与炎症和/或组织坏死相关的术后并发症。血清C反应蛋白水平在术后6小时内开始升高，在第二天达到峰值，到术后第三天开始降至术前水平。在涉及炎症的手术并发症病例中，血清C反应蛋白水平持续升高，术后第三天没有下降。发现其他“急性期蛋白”如α1酸性糖蛋白、铜蓝蛋白、α1抗胰蛋白酶和触珠蛋白的血清水平在手术过程中会升高，但在C反应蛋白升高之后。这些其他蛋白在监测术后急性期反应方面没有提供额外信息。
