Saarnivaara L, Männistö P T
Arch Int Pharmacodyn Ther. 1976 Aug;222(2):282-92.
The effects of acute and chronic LiCl and RbCl treatments on the antinociception caused by morphine, pethidine, methadone, pentazocine, nalorphine or naloxone were studied in mice using the hot plate and phenylquinone writhing tests. In both tests morphine, pethidine, and methadone caused significant antinociception whereas the antagonistic drugs were almost inactive. In the hot plate test both the 21 day administration of LiCl and the 5 and 21 day administration of RbCl decreased the antinociceptive effect of morphine. The 5 day administration of LiCl increased the antinociceptive effect of pethidine whereas the acute and 5 day administrations of RbCl abolished it. There were no significant or consistent interactions of the ions with the antinociceptive effect of methadone or the antagonistic drugs. In the phenylquinone writhing test the effects of the ions were inconsistent. Especially in the acute experiments where LiCl and RbCl had some effects on the behaviour of the mice treated with the analgesics, LiCl mostly impaired motor coordination and motor activity whereas RbCl was inactive or had opposite effects. LiCl enhanced the decrease in rectal temperature whereas RbCl was mostly inactive.
利用热板法和苯醌扭体试验，研究了急性和慢性氯化锂（LiCl）及氯化铷（RbCl）处理对吗啡、哌替啶、美沙酮、喷他佐辛、烯丙吗啡或纳洛酮所致小鼠镇痛作用的影响。在这两种试验中，吗啡、哌替啶和美沙酮均引起显著的镇痛作用，而拮抗药几乎无活性。在热板试验中，21天给予LiCl以及5天和21天给予RbCl均降低了吗啡的镇痛作用。5天给予LiCl增强了哌替啶的镇痛作用，而急性给予及5天给予RbCl则消除了该作用。这些离子与美沙酮或拮抗药的镇痛作用之间未出现显著或一致的相互作用。在苯醌扭体试验中，离子的作用并不一致。特别是在急性实验中，LiCl和RbCl对用镇痛药处理的小鼠行为有一些影响，LiCl大多损害运动协调性和运动活性，而RbCl无活性或有相反作用。LiCl增强了直肠温度的降低，而RbCl大多无活性。
