Männistö P T, Saarnivaara L
Arch Int Pharmacodyn Ther. 1976 Aug;222(2):293-9.
The effects of LiCl and RbCl on the antinociception caused by three antidepressants and pimozide were studied in mice. On the hot plate LiCl given acutely or chronically did not modify the antinociception of any drug although it augmented hypothermia induced by chlorimipramine and occasionally also that caused by desipramine and doxepine, and also caused definitive changes in motor abilities. RbCl given acutely (2.5 mEq/kg) or for 5 or 21 days in tap water (1 g/liter) abolished the antinociception caused by pimozide and when given acutely or for 5 days that of desipramine. In the phenylquinone writhing test LiCl when given for 21 days enhanced the nearly complete antinociception caused by chlorimipramine, doxepine and pimozide. These effects of ions did not seem to be related to changes in body temperature, motor coordination nor motility.
在小鼠中研究了氯化锂（LiCl）和氯化铷（RbCl）对三种抗抑郁药和匹莫齐特所致抗伤害感受的影响。在热板试验中，急性或慢性给予LiCl均未改变任何药物的抗伤害感受，尽管它增强了氯米帕明诱导的体温过低，偶尔也增强了地昔帕明和多塞平引起的体温过低，并且还导致运动能力发生明显变化。急性给予RbCl（2.5 mEq/kg）或在自来水中（1 g/升）给予5天或21天可消除匹莫齐特引起的抗伤害感受，急性给予或给予5天时可消除地昔帕明引起的抗伤害感受。在苯醌扭体试验中，给予LiCl 21天可增强氯米帕明、多塞平和匹莫齐特引起的几乎完全的抗伤害感受。离子的这些作用似乎与体温、运动协调性或运动能力的变化无关。
