Case D C, Hansen J A, Corrales E, Young C W, Dupont B, Pinsky C M, Good R A
Cancer. 1976 Oct;38(4):1807-15. doi: 10.1002/1097-0142(197610)38:4<1807::aid-cncr2820380458>3.0.co;2-y.
Multiple in vivo and in vitro immune parameters were used to examine 52 untreated patients with Hodgkin's disease in all stages. A significant number (p less than 0.01) of patients in all stages demonstrated abnormalities in DNCB sensitization, peripheral blood lymphocyte response to phytohemagglutination, absolute lymphocyte count, absolute number of T cells (as measured by spontaneous rosette formation with sheep erythrocytes), and absolute number of B cells (as measured by immunofluorescence with polyvalent antiserum). The number of T and B cells fell progressively with each stage, but the proportion of T to B cells remained constant. Cutaneous anergy was found in STAGES III and IV. Depressed circulating immunoglobulins were found in a few patients in all stages. Neither the total lymphocyte number nor the number of T and B cells correlated with the measures of lymphocyte function (skin test reactivity, DNCB sensitization, mitogen response, or immunoglobulin levels). This study suggests that selective abnormalities in the immune system exist even in early Hodgkin's disease, involving the absolute number of circulating T and B lymphocytes and T-lymphocyte function. The study fails, however, to define a consistent pattern of immune defects as characteristic of Hodgkin's Disease.
采用多种体内和体外免疫参数对52例未经治疗的各期霍奇金病患者进行了检查。所有分期的大量患者（p<0.01）在二硝基氯苯致敏、外周血淋巴细胞对植物血凝素的反应、绝对淋巴细胞计数、T细胞绝对数（通过与绵羊红细胞自发形成玫瑰花结来测量）和B细胞绝对数（通过用多价抗血清进行免疫荧光测量）方面均表现异常。T细胞和B细胞的数量随分期逐渐减少，但T细胞与B细胞的比例保持恒定。在Ⅲ期和Ⅳ期发现皮肤无反应性。在所有分期的少数患者中发现循环免疫球蛋白降低。淋巴细胞总数以及T细胞和B细胞的数量均与淋巴细胞功能指标（皮肤试验反应性、二硝基氯苯致敏、有丝分裂原反应或免疫球蛋白水平）无关。本研究表明，即使在早期霍奇金病中也存在免疫系统的选择性异常，涉及循环T淋巴细胞和B淋巴细胞的绝对数量以及T淋巴细胞功能。然而，该研究未能确定一种作为霍奇金病特征的一致的免疫缺陷模式。
