霍奇金病中单核细胞介导的抗体依赖性细胞毒性（ADCC）增加。
Increased monocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) in Hodgkin's disease.
作者信息
Pehamberger H, Ludwig H, Pötzi P, Knapp W
出版信息
Br J Cancer. 1980 May;41(5):778-81. doi: 10.1038/bjc.1980.141.
Abstract
Monocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) was tested in 23 patients with histologically proven Hodgkin's disease and 29 healthy normal controls. Seven patients presented with active and 16 with inactive disease. The lytic capacity of the individual monocytes was significantly (P < 0.02) higher in patients with Hodgkin's disease than in normals. However, no significant difference was found between the numbers of monocytes in both groups of individuals, as determined by non-specific esterase staining. No correlation was found between the lytic capacity of monocytes and the activity of the disease.
摘要
在23例经组织学证实为霍奇金病的患者和29名健康正常对照者中检测了单核细胞介导的抗体依赖性细胞毒性（ADCC）。7例患者患有活动性疾病，16例患有非活动性疾病。霍奇金病患者单个单核细胞的溶解能力显著高于正常人（P < 0.02）。然而，通过非特异性酯酶染色测定，两组个体的单核细胞数量之间未发现显著差异。单核细胞的溶解能力与疾病活动度之间未发现相关性。
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