镉诱导大鼠阳离子渗透性溶血的变化。

Cadmium-induced changes in cation-osmotic haemolysis in rats.

作者信息

Ján M, Frantisek N

机构信息

Department of Pharmacology, Medical Faculty, P.J. Safarik University, Tr. SNP 1, 040 66, Kosice, Slovak Republic

出版信息

Environ Toxicol Pharmacol. 2000 Jan 1;8(2):79-81. doi: 10.1016/s1382-6689(99)00036-8.

DOI:10.1016/s1382-6689(99)00036-8

PMID:10867366

Abstract

Erythrocyte microrheology changes were measured using cation-osmotic haemolysis (COH) in healthy rats and rats after 6 and 12 months of cadmium ingestion. Using COH properties of two membrane constituents, spectrine membrane skeleton and membrane bilayer, were studied. COH in rats after 6 months of cadmium ingestion was significantly lower only in the area with lower ionic strength. However, longer intake of cadmium (12 months) induced decrease of COH in both areas, with lower and also with higher ionic strength. The relation between cation-osmotic haemolysis and erythrocyte deformability is being discussed.

摘要

使用阳离子渗透溶血法（COH）测量了健康大鼠以及摄入镉6个月和12个月后的大鼠的红细胞微观流变学变化。利用COH特性研究了两种膜成分，即血影蛋白膜骨架和膜双层。摄入镉6个月后的大鼠，仅在离子强度较低的区域，COH显著降低。然而，镉摄入时间更长（12个月）会导致两个区域的COH均下降，包括离子强度较低和较高的区域。本文还讨论了阳离子渗透溶血与红细胞变形性之间的关系。