补体在非免疫宿主抵御实验性b型流感嗜血杆菌败血症和脑膜炎中的作用。
Participation of complement in the nonimmune host defense against experimental Haemophilus influenzae type b septicemia and meningitis.
作者信息
Crosson F J, Winkelstein J A, Moxon E R
出版信息
Infect Immun. 1976 Oct;14(4):882-7. doi: 10.1128/iai.14.4.882-887.1976.
Abstract
This study was undertaken to determine whether the terminal complement components (C3-9) are involved in the nonimmune host defense against Haemophilus influenzae type b septicemia and meningitis. Using cobra venom factor, infant rats were depleted of C3 and C5. After intranasal challenge with H. influenzae type b, the complement-depleted rats developed a greater incidence and magnitude of bacteremia and a higher mortality rate. In contrast to the effects on bacteremia, complement depletion did not directly influence either the occurrence of meningitis or bacterial multiplication within the cerebrospinal fluid. These experiments provide evidence that the complement system may be an important mechanism of natural immunity to H. influenzae type b.
摘要
本研究旨在确定终末补体成分（C3 - 9）是否参与针对b型流感嗜血杆菌败血症和脑膜炎的非免疫宿主防御。使用眼镜蛇毒因子使幼鼠的C3和C5耗竭。在用b型流感嗜血杆菌进行鼻内攻击后，补体耗竭的大鼠发生菌血症的发生率和程度更高，死亡率也更高。与对菌血症的影响相反，补体耗竭并未直接影响脑膜炎的发生或脑脊液内的细菌繁殖。这些实验提供了证据，表明补体系统可能是针对b型流感嗜血杆菌的天然免疫的重要机制。
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