b型流感嗜血杆菌脑膜炎幼鼠实验模型的免疫学
Immunology of the infant rat experimental model of Haemophilus influenzae type b meningitis.
作者信息
Myerowitz R L, Norden C W
出版信息
Infect Immun. 1977 Apr;16(1):218-25. doi: 10.1128/iai.16.1.218-225.1977.
Abstract
The age-related acquisition of serum anticapsular and bactericidal antibodies to Haemophilus influenzae type b observed in rats was similar to that of humans. The antigenic source for this "natural" immunity was not identified since neither pharyngeal infection with H. influenzae b nor enteric colonization by cross-reacting bacteria was detected. Infant rats surviving H. influenzae b bacteremia failed to respond immunologically to the capsular polysaccharide. However, surviving rats demonstrated no impairment of immune responsiveness to this antigen after subsequent immunization with live bacteria in adulthood. In passive protection experiments, antibodies directed against the type b capsular polysaccharide represented the major protective specificity. However, a small protective effect of antibodies to noncapsular antigens also appeared to have been demonstrated.
摘要
在大鼠中观察到的与年龄相关的针对b型流感嗜血杆菌的血清抗荚膜和杀菌抗体的获得情况与人类相似。由于未检测到b型流感嗜血杆菌的咽部感染或交叉反应细菌的肠道定植，这种“天然”免疫的抗原来源尚未确定。在b型流感嗜血杆菌菌血症中存活的幼鼠对荚膜多糖没有免疫反应。然而，存活的大鼠在成年后用活细菌进行后续免疫后，对该抗原的免疫反应性没有受损。在被动保护实验中，针对b型荚膜多糖的抗体代表了主要的保护特异性。然而，针对非荚膜抗原的抗体似乎也显示出了较小的保护作用。
相似文献
1
Immunology of the infant rat experimental model of Haemophilus influenzae type b meningitis.b型流感嗜血杆菌脑膜炎幼鼠实验模型的免疫学
Infect Immun. 1977 Apr;16(1):218-25. doi: 10.1128/iai.16.1.218-225.1977.
2
Further studies of the role of noncapsular antibody in protection against experimental Haemophilus influenzae type b bacteremia.关于非荚膜抗体在预防实验性b型流感嗜血杆菌菌血症中作用的进一步研究。
Infect Immun. 1983 Oct;42(1):257-63. doi: 10.1128/iai.42.1.257-263.1983.
3
Experimental Haemophilus influenzae type b meningitis: immunological investigation of the infant rat model.实验性b型流感嗜血杆菌脑膜炎：幼鼠模型的免疫学研究
Infect Immun. 1978 Jun;20(3):705-13. doi: 10.1128/iai.20.3.705-713.1978.
4
Experimental meningitis in the rat: Haemophilus influenzae.大鼠实验性脑膜炎：流感嗜血杆菌
Infection. 1984;12 Suppl 1:S11-22. doi: 10.1007/BF01641734.
5
Meningitis caused by Haemophilus influenzae in infant rats: protective immunity and antibody priming by gastrointestinal colonization with Escherichia coli.幼鼠中流感嗜血杆菌引起的脑膜炎：通过大肠杆菌胃肠道定植产生的保护性免疫和抗体启动
J Infect Dis. 1979 Oct;140(4):471-8. doi: 10.1093/infdis/140.4.471.
6
Induction of Haemophilus influenzae type b capsular antibody in neonatal rabbits by gastrointestinal colonization with cross-reacting Escherichia coli.通过与具有交叉反应性的大肠杆菌进行胃肠道定植诱导新生兔产生 b 型流感嗜血杆菌荚膜抗体。
Infect Immun. 1973 Feb;7(2):137-40. doi: 10.1128/iai.7.2.137-140.1973.
7
Further studies on the immunology of the infant rat experimental model of Haemophilus influenzae type B meningitis.对B型流感嗜血杆菌脑膜炎幼鼠实验模型免疫学的进一步研究。
Br J Exp Pathol. 1978 Oct;59(5):544-50.
8
Haemophilus influenzae type b: disease and immunity in humans.b型流感嗜血杆菌：人类疾病与免疫
Ann Intern Med. 1973 Feb;78(2):259-69. doi: 10.7326/0003-4819-78-2-259.
9
[Fetal and neonatal transmission of type-b anti-haemophilus influenzae antibodies protecting the newborn rat].[B型抗流感嗜血杆菌抗体的胎儿及新生儿传播对新生大鼠的保护作用]
Pathol Biol (Paris). 1983 Feb;31(2):138-40.
10
Age-related susceptibility to Haemophilus influenzae type b disease in rabbits.兔对b型流感嗜血杆菌疾病的年龄相关性易感性。
Infect Immun. 1971 Oct;4(4):397-401. doi: 10.1128/iai.4.4.397-401.1971.
引用本文的文献
1
Experimental meningitis in the rat: Haemophilus influenzae.大鼠实验性脑膜炎：流感嗜血杆菌
Infection. 1984;12 Suppl 1:S11-22. doi: 10.1007/BF01641734.
2
Phenotypic and genetic variation in the susceptibility of Haemophilus influenzae type b to antibodies to somatic antigens.b型流感嗜血杆菌对体细胞抗原抗体易感性的表型和遗传变异
J Clin Invest. 1980 Apr;65(4):885-91. doi: 10.1172/JCI109741.
3
Effect of neonatal gastrointestinal colonization with cross reacting Escherichia coli on anticapsular antibody production and bacteremia in experimental Haemophilus influenzae type b disease of rats.新生大鼠胃肠道被交叉反应性大肠杆菌定植对实验性b型流感嗜血杆菌病中抗荚膜抗体产生及菌血症的影响
Infect Immun. 1977 Jul;17(1):83-90. doi: 10.1128/iai.17.1.83-90.1977.
4
Further studies on the immunology of the infant rat experimental model of Haemophilus influenzae type B meningitis.对B型流感嗜血杆菌脑膜炎幼鼠实验模型免疫学的进一步研究。
Br J Exp Pathol. 1978 Oct;59(5):544-50.
5
Experimental Haemophilus influenzae type b meningitis: immunological investigation of the infant rat model.实验性b型流感嗜血杆菌脑膜炎：幼鼠模型的免疫学研究
Infect Immun. 1978 Jun;20(3):705-13. doi: 10.1128/iai.20.3.705-713.1978.
6
Characterization of the immunoprotective antigen of ribosomal preparations from Haemophilus influenzae.流感嗜血杆菌核糖体制剂免疫保护性抗原的特性分析
Infect Immun. 1978 Jan;19(1):58-65. doi: 10.1128/iai.19.1.58-65.1978.
7
Significance of noncapsular antigens in protection against experimental Haemophilus influenzae type b disease: cross-reactivity.非荚膜抗原在预防实验性b型流感嗜血杆菌疾病中的意义：交叉反应性。
Infect Immun. 1978 Aug;21(2):619-26. doi: 10.1128/iai.21.2.619-626.1978.
本文引用的文献
1
BACTERIAL MENINGITIS--A REVIEW OF SELECTED ASPECTS. 1. GENERAL CLINICAL FEATURES, SPECIAL PROBLEMS AND UNUSUAL MENINGEAL REACTIONS MIMICKING BACTERIAL MENINGITIS.细菌性脑膜炎——部分方面综述。1. 一般临床特征、特殊问题及类似细菌性脑膜炎的异常脑膜反应
N Engl J Med. 1965 Apr 8;272:725-31 CONTD. doi: 10.1056/NEJM196504082721406.
2
Studies on the mechanism of the immunological paralysis induced in mice by pneumococcal polysaccharides.肺炎球菌多糖诱导小鼠免疫麻痹机制的研究。
J Immunol. 1955 Jan;74(1):17-26.
3
Reassessment of the role of bactericidal antibody in Hemophilus influenzae infection.对杀菌性抗体在流感嗜血杆菌感染中作用的重新评估。
Am J Med Sci. 1971 Dec;262(6):338-46. doi: 10.1097/00000441-197112000-00005.
4
Immunity to disease caused by Hemophilus influenzae type b. II. Specificity and some biologic characteristics of "natural," infection-acquired, and immunization-induced antibodies to the capsular polysaccharide of Hemophilus influenzae type b.b型流感嗜血杆菌引起疾病的免疫性。二、针对b型流感嗜血杆菌荚膜多糖的“天然”、感染获得性及免疫诱导性抗体的特异性及某些生物学特性。
J Immunol. 1971 Oct;107(4):1081-9.
5
Immunity to Haemophilus influenzae type B: the role of the capsular antibody.对B型流感嗜血杆菌的免疫：荚膜抗体的作用。
J Med Microbiol. 1971 Feb;4(1):85-8. doi: 10.1099/00222615-4-1-85.
6
Immunologic responses to Hemophilus influenzae meningitis.对流感嗜血杆菌脑膜炎的免疫反应。
J Pediatr. 1972 Feb;80(2):209-14. doi: 10.1016/s0022-3476(72)80580-8.
7
Haemophilus influenzae meningitis in infant rats after intranasal inoculation.经鼻接种后幼鼠的流感嗜血杆菌脑膜炎
J Infect Dis. 1974 Feb;129(2):154-62. doi: 10.1093/infdis/129.2.154.
8
Haemophilus influenzae type b: disease and immunity in humans.b型流感嗜血杆菌：人类疾病与免疫
Ann Intern Med. 1973 Feb;78(2):259-69. doi: 10.7326/0003-4819-78-2-259.
9
Prevalence of bactericidal antibodies to Haemophilus influenzae, type b.b型流感嗜血杆菌杀菌抗体的患病率
J Infect Dis. 1974 Nov;130(5):489-94. doi: 10.1093/infdis/130.5.489.
10
Immunologic response in patients with epiglottitis caused by Haemophilus influenzae type b.由b型流感嗜血杆菌引起的会厌炎患者的免疫反应。
J Infect Dis. 1973 Dec;128(6):777-80. doi: 10.1093/infdis/128.6.777.
Zotero 插件