补体耗竭对针对b型流感嗜血杆菌实验性感染的抗荚膜抗体介导免疫的影响。
Effect of complement depletion on anticapsular-antibody-mediated immunity to experimental infection with Haemophilus influenzae type b.
作者信息
Schreiber J R, Basker C J, Siber G R
机构信息
Laboratory of Infectious Diseases, Dana Farber Cancer Institute, Boston, Massachusetts 02115.
出版信息
Infect Immun. 1987 Nov;55(11):2830-3. doi: 10.1128/iai.55.11.2830-2833.1987.
Abstract
Antibody to the capsular polysaccharide of Haemophilus influenzae type b (Hib) was not protective in infant rats depleted of complement by cobra venom factor (CoVF) even when serum antibody levels were many times the minimum protective level. Partial protection from Hib infection was achieved in CoVF-treated rats only if they were passively hyperimmunized with large doses of immunoglobulin G Hib capsular polysaccharide antibody. In addition, nonimmune CoVF-treated rats had higher mortality and blood bacterial density than nonimmune rats with intact complement systems.
摘要
针对b型流感嗜血杆菌（Hib）荚膜多糖的抗体，在被眼镜蛇毒因子（CoVF）耗尽补体的幼鼠中没有保护作用，即使血清抗体水平是最低保护水平的许多倍。只有当用大剂量免疫球蛋白G Hib荚膜多糖抗体对CoVF处理的大鼠进行被动超免疫时，才能实现对Hib感染的部分保护。此外，未免疫的CoVF处理大鼠比补体系统完整的未免疫大鼠具有更高的死亡率和血液细菌密度。
相似文献
1
Effect of complement depletion on anticapsular-antibody-mediated immunity to experimental infection with Haemophilus influenzae type b.补体耗竭对针对b型流感嗜血杆菌实验性感染的抗荚膜抗体介导免疫的影响。
Infect Immun. 1987 Nov;55(11):2830-3. doi: 10.1128/iai.55.11.2830-2833.1987.
2
Functional characterization of human IgG, IgM, and IgA antibody directed to the capsule of Haemophilus influenzae type b.针对b型流感嗜血杆菌荚膜的人IgG、IgM和IgA抗体的功能特性
J Infect Dis. 1986 Jan;153(1):8-16. doi: 10.1093/infdis/153.1.8.
3
Mechanism of antibody-mediated reduction of nasopharyngeal colonization by Haemophilus influenzae type b studied in an infant rat model.在幼鼠模型中研究b型流感嗜血杆菌抗体介导的鼻咽部定植减少机制。
J Infect Dis. 1996 Dec;174(6):1337-40. doi: 10.1093/infdis/174.6.1337.
4
Further studies of the role of noncapsular antibody in protection against experimental Haemophilus influenzae type b bacteremia.关于非荚膜抗体在预防实验性b型流感嗜血杆菌菌血症中作用的进一步研究。
Infect Immun. 1983 Oct;42(1):257-63. doi: 10.1128/iai.42.1.257-263.1983.
5
6
Immunogenicity of Haemophilus influenzae type b polysaccharide-outer membrane protein conjugate vaccine in patients who acquired Haemophilus disease despite previous vaccination with type b polysaccharide vaccine.b型流感嗜血杆菌多糖-外膜蛋白结合疫苗在既往接种过b型多糖疫苗但仍患流感嗜血杆菌疾病患者中的免疫原性。
J Pediatr. 1989 Jun;114(6):925-33. doi: 10.1016/s0022-3476(89)80432-9.
7
Anti-capsular polysaccharide antibodies reduce nasopharyngeal colonization by Haemophilus influenzae type b in infant rats.抗荚膜多糖抗体可减少b型流感嗜血杆菌在幼鼠鼻咽部的定植。
J Infect Dis. 1993 Feb;167(2):365-71. doi: 10.1093/infdis/167.2.365.
8
Comparison of naturally acquired and vaccine-induced antibodies to Haemophilus influenzae type b capsular polysaccharide.自然获得的和疫苗诱导产生的针对b型流感嗜血杆菌荚膜多糖的抗体比较。
Infect Immun. 1993 Dec;61(12):5345-50. doi: 10.1128/iai.61.12.5345-5350.1993.
9
Anticapsular antibody requirements for protection against experimental Haemophilus influenzae type b bacteremia after splenectomy.脾切除术后预防实验性b型流感嗜血杆菌菌血症所需的抗荚膜抗体
Infect Immun. 1988 Apr;56(4):984-6. doi: 10.1128/iai.56.4.984-986.1988.
10
Naturally acquired antibodies against Haemophilus influenzae type a in Aboriginal adults, Canada.加拿大原住民成年人中自然获得的抗a型流感嗜血杆菌抗体。
Emerg Infect Dis. 2015 Feb;21(2):273-9. doi: 10.3201/eid2102.140722.
引用本文的文献
1
Two-component systems in Haemophilus influenzae: a regulatory role for ArcA in serum resistance.流感嗜血杆菌中的双组分系统：ArcA在血清抗性中的调节作用。
Infect Immun. 2003 Jan;71(1):163-72. doi: 10.1128/IAI.71.1.163-172.2003.
2
Outer membrane protein D15 is conserved among Haemophilus influenzae species and may represent a universal protective antigen against invasive disease.外膜蛋白D15在流感嗜血杆菌各菌株中具有保守性，可能是一种针对侵袭性疾病的通用保护性抗原。
Infect Immun. 1997 Sep;65(9):3701-7. doi: 10.1128/iai.65.9.3701-3707.1997.
3
Outer membrane protein binding sites of complement component 3 during opsonization of Haemophilus influenzae.流感嗜血杆菌调理作用过程中补体成分3的外膜蛋白结合位点
Infect Immun. 1993 Dec;61(12):5157-63. doi: 10.1128/iai.61.12.5157-5163.1993.
4
5
Complement component 3 binding to Haemophilus influenzae type b in the presence of anticapsular and anti-outer membrane antibodies.在存在抗荚膜抗体和抗外膜抗体的情况下，补体成分3与b型流感嗜血杆菌结合。
Infect Immun. 1992 Jan;60(1):19-24. doi: 10.1128/iai.60.1.19-24.1992.
本文引用的文献
1
The critical role of complement in experimental pneumococcal sepsis.补体在实验性肺炎球菌败血症中的关键作用。
J Infect Dis. 1980 Dec;142(6):903-9. doi: 10.1093/infdis/142.6.903.
2
3
Differential complement resistance mediates virulence of Haemophilus influenzae type b.补体抗性差异介导b型流感嗜血杆菌的毒力。
Infect Immun. 1982 Jan;35(1):95-104. doi: 10.1128/iai.35.1.95-104.1982.
4
Antibody-dependent alternative pathway killing of Haemophilus influenzae type b.抗体依赖性替代途径对b型流感嗜血杆菌的杀伤作用
Infect Immun. 1984 May;44(2):452-8. doi: 10.1128/iai.44.2.452-458.1984.
5
Preparation of human hyperimmune globulin to Haemophilus influenzae b, Streptococcus pneumoniae, and Neisseria meningitidis.针对 b 型流感嗜血杆菌、肺炎链球菌和脑膜炎奈瑟菌的人高免疫球蛋白的制备。
Infect Immun. 1984 Jul;45(1):248-54. doi: 10.1128/iai.45.1.248-254.1984.
6
Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides.通过卤化氰将肽和蛋白质与多糖进行化学偶联。
Nature. 1967 Jun 24;214(5095):1302-4. doi: 10.1038/2141302a0.
7
Immunity to disease caused by Hemophilus influenzae type b. II. Specificity and some biologic characteristics of "natural," infection-acquired, and immunization-induced antibodies to the capsular polysaccharide of Hemophilus influenzae type b.b型流感嗜血杆菌引起疾病的免疫性。二、针对b型流感嗜血杆菌荚膜多糖的“天然”、感染获得性及免疫诱导性抗体的特异性及某些生物学特性。
J Immunol. 1971 Oct;107(4):1081-9.
8
Selective enzyme purification by affinity chromatography.通过亲和色谱法进行选择性酶纯化。
Proc Natl Acad Sci U S A. 1968 Oct;61(2):636-43. doi: 10.1073/pnas.61.2.636.
9
A simplified method for cyanogen bromide activation of agarose for affinity chromatography.一种用于亲和色谱的琼脂糖溴化氰活化的简化方法。
Anal Biochem. 1974 Jul;60(1):149-52. doi: 10.1016/0003-2697(74)90139-0.
10
Characterization of human antibody to polyribophosphate, the capsular antigen of Hemophilus influenzae, type B.针对B型流感嗜血杆菌荚膜抗原多聚核糖磷酸的人源抗体的特性分析
Clin Immunol Immunopathol. 1973 Jan;1(2):234-40. doi: 10.1016/0090-1229(73)90024-x.
Zotero 插件