Kraemer G W, Klopf F H, McKinney W T
Psychopharmacology (Berl). 1979 Mar 14;61(1):103-4. doi: 10.1007/BF00426819.
Similar excitatory or depressant response rate dependent effects on monkeys responding on a variable interval reinforcement schedule were observed following intravenous administration of either thyrotropin releasing hormone (TRH) or thiobarbiturate. However, these agents were mutally antagonistic when given together even though the response rate altering effects of each agent were in the same direction. These findings establish an additional behavioral effect of exogenously administered TRH in primates and suggest that barbiturates might alter behavior in part through an interaction with brain TRH receptive mechanisms.
静脉注射促甲状腺激素释放激素（TRH）或硫喷妥酸盐后，观察到猴子在可变间隔强化程序下做出反应时，出现了类似的兴奋性或抑制性反应率依赖性效应。然而，尽管每种药物对反应率的改变作用方向相同，但当它们一起给药时却相互拮抗。这些发现确定了外源性给予TRH在灵长类动物中的另一种行为效应，并表明巴比妥类药物可能部分通过与脑TRH受体机制相互作用来改变行为。
