Winger G, Stitzer M L, Woods J H
J Pharmacol Exp Ther. 1975 Dec;195(3):505-14.
The rate and pattern of pressing a lever was studied in rhesus monkeys under conditions where each press led to the intravenous injection of a barbiturate or of saline. The reinforcing effect of the barbiturate was indicated by higher rates of responding on the lever that delivered drug than on the lever that did not and by lower rates of responding when saline was delivered instead of the barbiturate. Responding increased and was maintained by the following ranges of dose/injection: barbital (2.5-10.0 mg/kg), pentobarbital (0.25-4.0 mg/kg), amobarbital (0.25-4.0 mg/kg), thiopental (0.50-4.0 mg/kg) and methohexital (0.125-2.0 mg/kg). Response rates were inversely related to the dose delivered with each injection for each of the barbiturates over these ranges. Within 3-hour access periods, injections tended to occur in bursts followed by pauses.
在恒河猴身上研究了按压杠杆的速率和模式，实验条件为每次按压杠杆都会导致静脉注射巴比妥酸盐或生理盐水。与未注射药物的杠杆相比，注射药物的杠杆上更高的反应速率以及当注射生理盐水而非巴比妥酸盐时更低的反应速率，都表明了巴比妥酸盐的强化作用。在以下剂量/注射范围内，反应增加并得以维持：巴比妥（2.5 - 10.0毫克/千克）、戊巴比妥（0.25 - 4.0毫克/千克）、异戊巴比妥（0.25 - 4.0毫克/千克）、硫喷妥钠（0.50 - 4.0毫克/千克）和甲己炔巴比妥（0.125 - 2.0毫克/千克）。在这些范围内，每种巴比妥酸盐每次注射的给药剂量与反应速率呈负相关。在3小时的使用期内，注射往往呈突发状，随后有停顿。
