Metcalf D, Kolber S
Br J Cancer. 1976 Nov;34(5):465-75. doi: 10.1038/bjc.1976.200.
Studies were made on the effects of 665 sera, from normal donors or patients with various diseases, on B-lymphocyte colony formation in agar by mouse spleen cells. Undiluted serum from most normal donors inhibited colony formation, but 43-53% of sera from patients with histiocytic lymphoma, lymphocytic lymphoma or Hodgkin's disease stimulated colony formation, serum activity correlating with the stage of the disease. Moderate colony-stimulating activity was observed with serum taken from patients with acute lymphoid or myeloid leukaemia following, but not prior to, chemotherapy. Colony stimulating activity was not correlated with the blood group of serum donors and could not be ascribed to the presence of endotoxin, red cells or mouse red cell haemagglutinins in the active sera. Elevated colony stimulating activity was not observed in sera from patients with non-neoplastic disorders ot haemopoiesis or with diseases of other organ systems.
对来自正常供血者或患有各种疾病的患者的665份血清，进行了其对小鼠脾细胞在琼脂中形成B淋巴细胞集落影响的研究。大多数正常供血者的未稀释血清抑制集落形成，但43% - 53%的组织细胞淋巴瘤、淋巴细胞淋巴瘤或霍奇金病患者的血清刺激集落形成，血清活性与疾病分期相关。急性淋巴细胞白血病或髓细胞白血病患者化疗后而非化疗前采集的血清观察到中等程度的集落刺激活性。集落刺激活性与血清供血者的血型无关，且不能归因于活性血清中存在内毒素、红细胞或小鼠红细胞凝集素。在非肿瘤性造血疾病患者或其他器官系统疾病患者的血清中未观察到集落刺激活性升高。
