Metcalf D
Immunology. 1971 Sep;21(3):427-36.
Injection of endotoxin or flagellins to C57BL mice caused 50–100-fold elevations, maximal at 3–9 hours, in the capacity of the serum to stimulate granulocyte and macrophage colony formation by mouse bone marrow cells in agar cultures. This response was not elicited by a variety of foreign serum proteins. The response was radioresistant but preimmunized mice showed a specific depression of responsiveness on challenge with the same antigen.
给C57BL小鼠注射内毒素或鞭毛蛋白后,血清刺激小鼠骨髓细胞在琼脂培养物中形成粒细胞和巨噬细胞集落的能力在3至9小时达到最大值,升高了50至100倍。多种外源血清蛋白不会引发这种反应。该反应具有抗辐射性,但预先免疫的小鼠在用相同抗原攻击时显示出特异性的反应性降低。