一种用于研究人类α-1抗胰蛋白酶缺乏症的动物模型。
An animal model for the study of human alpha-1-antitrypsin deficiency.
作者信息
Martin J P, Hadchouel M, Gautier M, Luzeau R, Hugon R N, Daguet J P
出版信息
Biomedicine. 1976 Dec 5;25(9):319-20.
PMID:1087167
Abstract
Turkeys with "round heart disease" often have a deficiency in alpha1 globulin. Within their liver cells, PAS +, diastase resistant granules are present, and are remarkably similar to those of persons with inherited AAT deficiency. The electrophoretic patterns made according Fagerhol's method showed differences between the serum of healthy birds and the turkeys suffering from "round heart disease".
摘要
患有“圆心病”的火鸡通常缺乏α1球蛋白。在它们的肝细胞内，存在PAS阳性、抗淀粉酶颗粒，并且与遗传性α1抗胰蛋白酶缺乏症患者的颗粒非常相似。根据法格霍尔方法制作的电泳图谱显示，健康鸟类的血清与患有“圆心病”的火鸡血清之间存在差异。
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