Corbett E F, Michalak M
MRC Group in Molecular Biology of Membranes and the Department of Biochemistry, University of Alberta, Edmonton, AL, Canada T6G 2H7.
Trends Biochem Sci. 2000 Jul;25(7):307-11. doi: 10.1016/s0968-0004(00)01588-7.
For many years now, it has been known that Ca2+ is an important signaling molecule in the cytosol of the cell, but emerging evidence suggests that Ca2+ might also play a signaling role in the endoplasmic reticulum. For example, agonist-induced fluctuations in free Ca2+ concentration in the endoplasmic reticulum can affect many functions of the endoplasmic reticulum, including protein synthesis and modification, and interchaperone interactions.
多年来，人们已经知道钙离子是细胞胞质溶胶中的一种重要信号分子，但新出现的证据表明，钙离子在内质网中可能也发挥着信号传导作用。例如，激动剂诱导的内质网中游离钙离子浓度的波动会影响内质网的许多功能，包括蛋白质合成与修饰以及伴侣蛋白间的相互作用。
