Ibba M, Becker H D, Stathopoulos C, Tumbula D L, Söll D
Center for Biomolecular Recognition, Dept of Medical Biochemistry and Genetics, Laboratory B, The Panum Institute, Blegdamsvej 3c, DK-2200, Copenhagen N, Denmark.
Trends Biochem Sci. 2000 Jul;25(7):311-6. doi: 10.1016/s0968-0004(00)01600-5.
As originally postulated in Crick's Adaptor hypothesis, the faithful synthesis of proteins from messenger RNA is dependent on the presence of perfectly acylated tRNAs. The hypothesis also suggested that each aminoacyl-tRNA would be made by a unique enzyme. Recent data have now forced a revision of this latter point, with an increasingly diverse array of enzymes and pathways being implicated in aminoacyl-tRNA synthesis. These unexpected findings have far-reaching implications for our understanding of protein synthesis and its origins.
正如克里克的“适配器假说”最初所假定的那样，从信使核糖核酸（mRNA）中准确合成蛋白质依赖于完全酰化的转运核糖核酸（tRNA）的存在。该假说还提出，每种氨酰tRNA将由一种独特的酶合成。最近的数据迫使人们对后一点进行修正，越来越多不同种类的酶和途径参与到氨酰tRNA的合成过程中。这些意外的发现对我们理解蛋白质合成及其起源具有深远的意义。
