Canel C, Moraes R M, Dayan F E, Ferreira D
USDA, ARS, NPURU, National Center for Natural Products Research, University of Mississippi, University 38677, USA.
Phytochemistry. 2000 May;54(2):115-20. doi: 10.1016/s0031-9422(00)00094-7.
Podophyllin, an ethanolic extract of Podophyllum peltatum L. or P. emodi Wall (syn. P. hexandnum Royle), is a good source of the aryltetralin-type lignan, podophyllotoxin. The latter compound, as well as its congeners and derivatives exhibit pronounced biological activity mainly as strong antiviral agents and as antineoplastic drugs. The podophyllotoxin derivatives etoposide, etopophos (etoposide phosphate), and teniposide are thus successfully utilized in the treatment of a variety of malignant conditions. Continued research on the Podophyllum lignans is currently focused on structure optimization to generate derivatives with superior pharmacological profiles and broader therapeutic scope, and the development of alternative and renewable sources of podophyllotoxin.
鬼臼树脂是盾叶鬼臼或喜马拉雅鬼臼（同物异名：桃儿七）的乙醇提取物，是芳基四氢萘型木脂素鬼臼毒素的良好来源。后一种化合物及其同系物和衍生物主要作为强效抗病毒剂和抗肿瘤药物表现出显著的生物活性。因此，鬼臼毒素衍生物依托泊苷、磷酸依托泊苷（依托泊苷磷酸盐）和替尼泊苷已成功用于治疗多种恶性疾病。目前对鬼臼木脂素的持续研究集中在结构优化上，以产生具有更优药理特性和更广泛治疗范围的衍生物，以及开发鬼臼毒素的替代和可再生来源。
