Graeff F G, Leone C M
Psychopharmacology (Berl). 1979 Mar 14;61(1):91-6. doi: 10.1007/BF00426817.
Dose-effect curves for amphetamine on key-pecking behavior of pigeons maintained by two-component multiple schedules of shock postponement were determined. During the first experimental phase the response-shock interval (RS) was held constant and the shock-shock interval (SS) varied. Under these conditions, shock rate was greater during the component with the shorter SS. However, response rates were comparable in both components. Also, the magnitude of the response rate increments caused by appropriate doses of amphetamine during both schedule components were similar. During the second experimental phase, the SS was held constant and the RS varied. As a consequence, baseline response rate was considerably lower in the component with the longer RS than in the short RS component. Shock presentations were also less frequent during the former than during the latter component, but the differences in shock rate between the components were comparable or smaller than those observed during the first experimental phase. Under these conditions, the effects of amphetamine in the two schedules components were markedly different, lower response rates being considerably more increased than higher rates.
确定了苯丙胺对由双组分多重电击延迟时间表维持的鸽子啄键行为的剂量-效应曲线。在第一个实验阶段，反应-电击间隔（RS）保持恒定，电击-电击间隔（SS）变化。在这些条件下，SS较短的组分中的电击率更高。然而，两个组分中的反应率相当。此外，在两个时间表组分中，适当剂量的苯丙胺引起的反应率增加幅度相似。在第二个实验阶段，SS保持恒定，RS变化。结果，RS较长的组分中的基线反应率明显低于RS较短的组分。在前一组分中电击呈现也比后一组分中更不频繁，但组分之间的电击率差异与在第一个实验阶段观察到的相当或更小。在这些条件下，苯丙胺在两个时间表组分中的作用明显不同，较低的反应率比较高的反应率增加得更多。
