克罗恩病和溃疡性结肠炎患者对二硝基氯苯的无反应性及T淋巴细胞功能降低
Anergy to dinitrochlorobenzene and depression of T-lymphocytes in Crohn's disease and ulcerative colitis.
作者信息
Meyers S, Sacher D B, Taub R N, Janowitz H D
出版信息
Gut. 1976 Nov;17(11):911-5. doi: 10.1136/gut.17.11.911.
Skin reactivity to dinitrochlorobenzene (DNCB) and levels of circulating T-lymphocytes were measured in 15 patients with ulcerative colitis, 15 patients with Crohn's disease, and 12 normal control subjects. Diminished reactivity to DNCB was demonstrated in 87% of patients with Crohn's disease (P less than 0-001) and in 53% with ulcerative colitis (P less than 0-02), as compared with only 8-5% of controls; anergy was more frequent in Crohn's disease than in ulcerative colitis (P less than 0-05). Levels of circulating T-lymphoctes were also depressed in both Crohn's disease and ulcerative colitis (P less than 0-001) as compared with controls, with the values lower in Crohn's disease than in ulcerative colitis (P less than 0-02). There were no correlations of DNCB response with extent, duration, or severity of disease nor with T-cell levels within any patient group. These data provide further support for the concept that there is impairment of cell-mediated immunity among many patients with chronic inflammatory bowel disease, including both Crohn's disease and ulcerative colitis.
对15例溃疡性结肠炎患者、15例克罗恩病患者和12名正常对照者测量了皮肤对二硝基氯苯（DNCB）的反应性及循环T淋巴细胞水平。与仅8.5%的对照者相比，87%的克罗恩病患者（P<0.001）和53%的溃疡性结肠炎患者（P<0.02）对DNCB的反应性降低；无反应性在克罗恩病中比在溃疡性结肠炎中更常见（P<0.05）。与对照者相比，克罗恩病和溃疡性结肠炎患者的循环T淋巴细胞水平也降低（P<0.001），且克罗恩病患者的值低于溃疡性结肠炎患者（P<0.02）。在任何患者组中，DNCB反应与疾病的范围、持续时间或严重程度均无相关性，与T细胞水平也无相关性。这些数据进一步支持了这样一种观点，即包括克罗恩病和溃疡性结肠炎在内的许多慢性炎症性肠病患者存在细胞介导免疫受损。
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