Victorino R M, Hodgson H J
Dig Dis Sci. 1981 Sep;26(9):801-6. doi: 10.1007/BF01309612.
We investigated suppressor cell activity in the peripheral blood of 39 patients with inflammatory bowel disease (30 Crohn's disease and 9 ulcerative colitis) by the short-lived suppressor cell assay. There was a significant decrease in the suppressor cell activity in patients with inflammatory bowel disease (IBD), compared to 26 healthy subjects studied simultaneously. Five other patients with acute bacterial infections had normal suppressor activity. A group of 14 IBD patients was also investigated for concanavalin A-induced suppressor cell activity and decreased suppressor function was confirmed. A significant positive correlation was found between the two assays. A defect in suppressor cell activity may permit the expression or maintenance of immunologically mediated damage to the gut in IBD.
我们通过短寿命抑制细胞检测法，对39例炎症性肠病患者（30例克罗恩病和9例溃疡性结肠炎）外周血中的抑制细胞活性进行了研究。与同时研究的26名健康受试者相比，炎症性肠病（IBD）患者的抑制细胞活性显著降低。另外5例急性细菌感染患者的抑制活性正常。对一组14例IBD患者也进行了伴刀豆球蛋白A诱导的抑制细胞活性研究，并证实其抑制功能降低。两种检测方法之间存在显著的正相关。抑制细胞活性缺陷可能会使IBD中肠道免疫介导损伤得以表达或持续存在。
