Hartnoll G, Bétrémieux P, Modi N
University Hospital Lewisham, London SE13 6LH, UK.
Arch Dis Child Fetal Neonatal Ed. 2000 Jul;83(1):F56-9. doi: 10.1136/fn.83.1.f56.
Preterm birth is often associated with impaired growth. Small for gestational age status confers additional risk.
To determine the body water content of appropriately grown (AGA) and small for gestational age (SGA) preterm infants in order to provide a baseline for longitudinal studies of growth after preterm birth.
All infants born at the Hammersmith and Queen Charlotte's Hospitals between 25 and 30 weeks gestational age were eligible for entry into the study. Informed parental consent was obtained as soon after delivery as possible, after which the extracellular fluid content was determined by bromide dilution and total body water by H(2)(18)O dilution.
Forty two preterm infants were studied. SGA infants had a significantly higher body water content than AGA infants (906 (833-954) and 844 (637-958) ml/kg respectively; median (range); p = 0.019). There were no differences in extracellular and intracellular fluid volumes, nor in the ratio of extracellular to intracellular fluid. Estimates of relative adiposity suggest a body fat content of about 7% in AGA infants, assuming negligible fat content in SGA infants and lean body tissue hydration to be equivalent in the two groups.
Novel values for the body water composition of the SGA preterm infant at 25-30 weeks gestation are presented. The data do not support the view that SGA infants have extracellular dehydration, nor is their regulation of body water impaired.
早产常与生长发育受损相关。小于胎龄状态会带来额外风险。
确定适于胎龄（AGA）和小于胎龄（SGA）的早产儿的身体含水量，以便为早产出生后生长的纵向研究提供基线。
所有在哈默史密斯医院和夏洛特女王医院出生、孕龄在25至30周之间的婴儿均有资格进入本研究。在分娩后尽快获得家长的知情同意，之后通过溴化物稀释法测定细胞外液含量，通过H₂¹⁸O稀释法测定全身含水量。
对42例早产儿进行了研究。SGA婴儿的身体含水量显著高于AGA婴儿（分别为906（833 - 954）和844（637 - 958）ml/kg；中位数（范围）；p = 0.019）。细胞外液和细胞内液体积以及细胞外液与细胞内液的比例均无差异。相对肥胖度的估计表明，假设SGA婴儿脂肪含量可忽略不计且两组瘦体组织水合作用相当，AGA婴儿的体脂含量约为7%。
给出了孕龄在25 - 30周的SGA早产儿身体水成分的新数值。数据不支持SGA婴儿存在细胞外脱水的观点，也不支持其身体水分调节受损的观点。
