Paria B C, Lim H, Das S K, Reese J, Dey S K
Department of Pediatrics, Ralph L. Smith Research Center, University of Kansas Medical Center, Kansas City, KS 66160-7338, USA.
Semin Cell Dev Biol. 2000 Apr;11(2):67-76. doi: 10.1006/scdb.2000.0153.
Successful implantation is the result of an intimate 'cross-talk' between the blastocyst and uterus in a temporal and cell-specific manner. Thus, both the uterine and embryonic events must be examined to better understand this process. Although various aspects and molecules associated with these events have been explored, a comprehensive understanding of the implantation process is still very limited. In this review, we have highlighted the importance of the blastocyst's activity state and the receptive state of the uterus in determining the 'window' of implantation. In this context, we provide a testable scheme that signifies the important roles of various key molecules in embryo-uterine interactions during implantation.
成功着床是以时间和细胞特异性方式，在囊胚与子宫之间进行密切“对话”的结果。因此，必须同时研究子宫和胚胎事件，以便更好地理解这一过程。尽管已经对与这些事件相关的各个方面和分子进行了探索，但对着床过程的全面理解仍然非常有限。在本综述中，我们强调了囊胚的活性状态和子宫的接受状态在确定着床“窗口期”方面的重要性。在此背景下，我们提供了一个可验证的方案，该方案表明了各种关键分子在着床期间胚胎与子宫相互作用中的重要作用。
