Praveenkumar V, Kuttan R, Kuttan G
Amala Cancer Research Centre, Amala Nagar, Thrissur, India.
Indian J Exp Biol. 1997 Dec;35(12):1319-23.
Oral administration of septilin (100mg/animal/dose; five doses) was found to enhance natural killer cell mediated cytotoxicity and antibody-dependent cellular cytotoxicity in normal mice as well as tumour-bearing mice. Septilin treatment also activated the peritoneal macrophages which produced cytotoxicity to L929 cells. Septilin increased proliferation of bone-marrow cells and there was an increase in the number of alpha-naphthyl acetate esterase staining cells in the bone-marrow. In addition to the activation of cellular immunity, septilin was found to increase the number of antibody producing cells in the spleen and activation of antibody-dependent complement-mediated cell lysis. These studies justifies the use of this herbal preparation in improving immunocompetence in disease states.
研究发现，对正常小鼠以及荷瘤小鼠口服给予七味药（100毫克/动物/剂量；五剂）可增强自然杀伤细胞介导的细胞毒性和抗体依赖性细胞毒性。七味药治疗还激活了对L929细胞产生细胞毒性的腹腔巨噬细胞。七味药增加了骨髓细胞的增殖，并且骨髓中α-萘乙酸酯酶染色细胞的数量有所增加。除了激活细胞免疫外，还发现七味药增加了脾脏中抗体产生细胞的数量，并激活了抗体依赖性补体介导的细胞裂解。这些研究证明了这种草药制剂在改善疾病状态下免疫能力方面的应用价值。
