Wong Y C, Wang Y Z
Department of Anatomy, Faculty of Medicine, University of Hong Kong.
Int Rev Cytol. 2000;199:65-116. doi: 10.1016/s0074-7696(00)99002-8.
Epithelial-stromal interactions are important not only in growth, development, and functional cytodifferentiation of the prostate but also in derangements of prostate gland such as BPH and prostate carcinoma. This chapter explores the roles of epithelium and stroma during this delicate process and highlights the role and mutual influence of each on the other. It also examines the importance of ECM in mediating the effects of androgens and drawn attention to estrogen and genetic factors in the process. During this process of epithelial-stromal interaction, growth factors play a central role in mediating the interactions. This chapter focuses on the role of several growth factors including epidermal growth factor, fibroblast growth factor, transforming growth factor alpha, transforming growth factor beta, insulin-like growth factor-1, vascular endothelial growth factor, nerve growth factor, platelet-derived growth factor, and hepatocyte growth factor. This chapter emphasizes the importance of epithelial-stromal interactions in tumorigenesis and highlights the switch of paracrine to autocrine mode during the process of carcinogenesis.
上皮 - 基质相互作用不仅在前列腺的生长、发育和功能性细胞分化中起重要作用，而且在前列腺的紊乱状态如良性前列腺增生（BPH）和前列腺癌中也起重要作用。本章探讨上皮和基质在此微妙过程中的作用，并强调它们彼此之间的作用和相互影响。本章还研究了细胞外基质（ECM）在介导雄激素作用中的重要性，并关注该过程中的雌激素和遗传因素。在上皮 - 基质相互作用的这个过程中，生长因子在介导相互作用中起核心作用。本章重点介绍几种生长因子的作用，包括表皮生长因子、成纤维细胞生长因子、转化生长因子α、转化生长因子β、胰岛素样生长因子 -1、血管内皮生长因子、神经生长因子、血小板衍生生长因子和肝细胞生长因子。本章强调上皮 - 基质相互作用在肿瘤发生中的重要性，并突出了致癌过程中旁分泌向自分泌模式的转变。
