Castellano C
Psychopharmacology (Berl). 1979 Mar 29;62(1):35-40. doi: 10.1007/BF00426032.
The effects of mescaline and amphetamine were investigated in BALB/cJ (BALB) and C57BL/6J (C57) mice using the five-choice Yerkes--Thompson Bryant--Bovet-Nitti apparatus for patterns discrimination. Two sets of experiments were carried out. In the first set, pretrial administration of mescaline (5, 10, and 20 mg/kg) was followed by performance improvements in the C57 mice, while performances of the BALB strain were impaired by the treatment, as compared with those of the saline-injected (4 ml/kg) controls. The pretrial administration of amphetamine (0.1, 0.25, and 0.5 mg/kg) improved performances of both strains. In a second set of experiments, the same effects as in the pretrial experiments were observed in both strains following administration of mescaline (20 mg/kg) and amphetamine (0.5 mg/kg) immediately after each experimental session. No effect was evident when the drugs were injected 2 h after training, suggesting that effects of the pretrial treatments were due to influences of mescaline and amphetamine on the consolidation processes of the two strains of mice tested.
使用五选择耶基斯 - 汤普森·布莱恩特 - 博韦 - 尼蒂装置进行模式辨别，研究了麦司卡林和苯丙胺对BALB/cJ（BALB）和C57BL/6J（C57）小鼠的影响。进行了两组实验。在第一组实验中，对C57小鼠进行麦司卡林（5、10和20mg/kg）预处理后，其表现得到改善，而与注射生理盐水（4ml/kg）的对照组相比，BALB品系的表现因该处理而受损。苯丙胺（0.1、0.25和0.5mg/kg）预处理改善了两个品系的表现。在第二组实验中，在每次实验 session 后立即给予麦司卡林（20mg/kg）和苯丙胺（0.5mg/kg），两个品系均观察到与预处理实验相同的效果。在训练后2小时注射药物时没有明显效果，这表明预处理的效果是由于麦司卡林和苯丙胺对所测试的两个品系小鼠的巩固过程的影响。
