Castellano C
Psychopharmacology (Berl). 1980;67(3):235-9. doi: 10.1007/BF00431262.
Heroin was administered to DBA/2 and C57BL/6 mice, trained in the five-choice Yerkes-Thompson-Bryant-Bovet-Nitti apparatus for pattern discrimination, in two sets of experiments. In a first set, pretrial administrations of heroin (0.1, 0.25, or 0.5 mg/kg) improved performance in both strains. In a second set, heroin (0.5 mg/kg) immediately following each training session were followed by performance improvements in both strains, while the performance of C57 mice was improved and that of the DBA mice was impaired by 5 mg/kg of opiate. No effect was evident in this set of experiments when heroin was injected 2 h after each session, suggesting that effects of the pretrial treatments were due to influences of the opiate on the consolidation processes of the strains tested.
在两组实验中，将海洛因注射给在用于模式辨别训练的五选择耶基斯 - 汤普森 - 布莱恩特 - 博韦 - 尼蒂装置中训练过的DBA/2和C57BL/6小鼠。在第一组实验中，海洛因（0.1、0.25或0.5毫克/千克）的预试验给药提高了两个品系小鼠的表现。在第二组实验中，每次训练后立即注射海洛因（0.5毫克/千克），两个品系小鼠的表现均得到改善，而5毫克/千克的阿片类药物使C57小鼠的表现得到改善，DBA小鼠的表现受损。当在每次训练后2小时注射海洛因时，在这组实验中没有明显效果，这表明预试验处理的效果是由于阿片类药物对受试品系巩固过程的影响。
