Perenyi A, Johann-Liang R, Stavola J J
Division of Neonatology, New York Hospital-Cornell University Medical College, New York, USA.
Am J Perinatol. 1999;16(10):525-30. doi: 10.1055/s-1999-7282.
Based on the recognition that interleukin-6 (IL-6) is produced early in infection, IL-6 determinations have been used to identify infants with early onset bacterial sepsis. This study intended to assess the value of IL-6 in maternal, cord and infant peripheral blood as an index of sepsis, and examine the relationships of its values in mother and infants. The population consisted of 17 mother/infant pairs at high risk for neonatal infection. Eight of these infants had clinical signs of possible sepsis. Cord blood IL-6 levels in infants of mothers considered to be noninfected were lower than those born to women with chorioamnionitis. There was also a positive correlation between maternal and cord blood IL-6 values. There were no differences in maternal blood IL-6, whether they had infections or not. Also, peripheral infant blood obtained after birth did not differentiate between those born to women with or without chorioamnionitis, nor did it correlate with maternal blood IL-6 levels. Clinical symptoms of the infants did not correlate with either cord or peripheral blood IL-6 values. Although maternal prepartum treatment with antibiotics and/or steroids may influence their own and their infants' blood IL-6 levels, there is insufficient evidence to consider low infant blood IL-6 level a reliable predictor to rule out early newborn sepsis.
基于白细胞介素-6（IL-6）在感染早期产生这一认识，IL-6检测已被用于识别早发型细菌性败血症婴儿。本研究旨在评估母体、脐带血和婴儿外周血中IL-6作为败血症指标的价值，并研究其在母亲和婴儿体内数值的关系。研究对象为17对有新生儿感染高风险的母婴。其中8名婴儿有疑似败血症的临床体征。被认为未感染的母亲所生婴儿的脐带血IL-6水平低于患有绒毛膜羊膜炎的母亲所生婴儿。母体和脐带血IL-6数值之间也存在正相关。无论母亲是否感染，其血液中的IL-6均无差异。此外，出生后采集的婴儿外周血无法区分患有或未患有绒毛膜羊膜炎的母亲所生婴儿，也与母体血液IL-6水平无关。婴儿的临床症状与脐带血或外周血IL-6数值均无关联。尽管母亲产前使用抗生素和/或类固醇可能会影响她们自身及婴儿血液中的IL-6水平，但尚无足够证据将婴儿血液中低IL-6水平视为排除早期新生儿败血症的可靠预测指标。
