Koyuncuoğlu H, Güngör M, Eroğlu L, Sağduyu H
Psychopharmacology (Berl). 1979 Mar 29;62(1):89-95. doi: 10.1007/BF00426041.
We have previously demonstrated the antagonizing effect of aspartic acid on some effects of morphine and on the development of physical dependence on, and tolerance to, morphine. In the present study, we have withdrawal from morphine or administration of a morphine antagonist. For this purpose sixty five white rats were given morphine and aspartic acid separately and in combination in a 5% saccharose solution instead of drinking water for 30 days. Some of the dependent rats were then withdrawn and others were injected with levallorphan. Flying, jumping, wet-dog shaking, body weight loss and motor activity were estimated and free amino acid levels in the brain were determined. Aspartic acid was found to prevent or antagonize the behavioural signs and the changes in the free amino acid levels in the brain. The results are discussed in the light of the previous data.
我们之前已经证明了天冬氨酸对吗啡某些作用以及对吗啡身体依赖性和耐受性发展的拮抗作用。在本研究中，我们进行了吗啡撤药或给予吗啡拮抗剂的操作。为此，65只白鼠分别单独或联合给予吗啡和天冬氨酸，置于5%蔗糖溶液而非饮用水中30天。然后让一些依赖吗啡的大鼠撤药，另一些注射烯丙左吗喃。评估了飞翔、跳跃、湿狗样抖动、体重减轻和运动活性，并测定了大脑中的游离氨基酸水平。发现天冬氨酸可预防或拮抗行为体征以及大脑中游离氨基酸水平的变化。根据先前的数据对结果进行了讨论。
