Effect of nialamide and reserpine on brain free amino acids of rat dependent on and withdrawn from morphine.

The brain free amino acid levels were estimated in rats dependent on and withdrawn from morphine. The effects of nialamide and reserpine on the levels of brain free amino acids were investigated during the development of physical dependence on morphine and after the abrupt withdrawal of morphine. The relationships between brain free amino acid levels, and physical dependence and withdrawal syndrome, the relationships between the degree of the manifestations in abstinence under the effects of nialamide and reserpine, and the changes in brain amino acid levels are discussed.