Meng R, Liebson P R, Hollander C, Teran L C, Barresil V
Br Heart J. 1976 Nov;38(11):1166-72. doi: 10.1136/hrt.38.11.1166.
Serial recording of systolic time intervals (STI) was used to assess changes in left ventricular (LV) function in 92 patients with stable angina undergoing coronary angiography and LV cineangiography. On the basis of angiography, patients were placed in the following study groups: mild or absent coronary artery disease group -21 patients with less than 70 per cent occlusion of all coronary arteries, considered to have non-significant coronary artery disease and not needing bypass surgery; surgical bypass group-52 patients with evidence of significant (less than 70%) obstruction of at least one coronary artery who underwent myocardial revascularization; and medical group-19 patients with evidence of significant coronary artery disease not undergoing bypass surgery. Measured STI, corrected for heart rate and sex, were expressed as indices. No significant differences were noted in the mean STI from the time of initial evaluation to second evaluation 3 to 6 months later in either the mold or absent coronary artery disease patients or the medical group. In the surgical bypass group, however, serial studies at initial angiographic evaulation and 3 to 6 months after bypass surgery showed a shortened pre-ejection period (PEP) from 150 +/- 20 to 142 +/- 16 mn (P less than 0-001), prolonged left ventricular ejection time (LVET) from 396 +/- 21 to 409 +/- 14 ms (P less than 0-02), and decreased PEP/LVET from 0-45 +/- 0-11 to 0-04 +/- 0-07 (P less than 0-02). Paired data analysis of the three groups also showed a significant change only within the surgical bypass group from initial to find study, with a shortened PEP (P less than 0-002), prolonged LVET (P less than 0-001), and decreased PEP/LVET (P less than 0-001). These data suggest improvement in LV function in patients with significant coronary artery disease within a few months of myocardial revascularization, without demonstrable change in STI in those patients with coronary artery disease not subjected to revascularization.
采用连续记录收缩期时间间期（STI）的方法，对92例接受冠状动脉造影和左心室电影血管造影的稳定型心绞痛患者的左心室（LV）功能变化进行评估。根据血管造影结果，将患者分为以下研究组：轻度或无冠状动脉疾病组——21例所有冠状动脉阻塞小于70%的患者，被认为患有非显著性冠状动脉疾病且无需搭桥手术；手术搭桥组——52例至少有一支冠状动脉存在明显（小于70%）阻塞并接受心肌血运重建的患者；药物治疗组——19例有明显冠状动脉疾病但未接受搭桥手术的患者。经心率和性别校正后的测量STI以指数形式表示。在轻度或无冠状动脉疾病患者或药物治疗组中，从初次评估到3至6个月后的第二次评估，平均STI未发现显著差异。然而，在手术搭桥组中，初次血管造影评估时和搭桥手术后3至6个月的系列研究显示，射血前期（PEP）从150±20毫秒缩短至142±16毫秒（P＜0.001），左心室射血时间（LVET）从396±21毫秒延长至409±14毫秒（P＜0.02），PEP/LVET从0.45±0.11降至0.40±0.07（P＜0.02）。三组的配对数据分析也显示，仅手术搭桥组从初次到最终研究有显著变化，PEP缩短（P＜0.002），LVET延长（P＜0.001），PEP/LVET降低（P＜0.001）。这些数据表明，在心肌血运重建后的几个月内，有显著冠状动脉疾病的患者左心室功能得到改善，而未进行血运重建的冠状动脉疾病患者的STI无明显变化。
