Garner A, Rahi A H
Br J Ophthalmol. 1976 Oct;60(10):684-6. doi: 10.1136/bjo.60.10.684.
Serological studies in 22 patients presenting with ocular disease attributable to dosage with the beta-blocking agent practolol revealed a raised incidence of antinuclear antibodies. There was also a marginal increase in the incidence of antibodies to smooth muscle in the more severely affected individuals but the incidence of ther autoantibodies and levels of IgG, IgA, and IgM were within normal limits. Semi-quantitative analysis of tears from 14 of the patients showed absence or near absence in the more severely affected patients of secretory IgA, which is indicative of damage to the lacrimal gland. Other immunological parameters in the tears were normal.
对22例因使用β受体阻滞剂心得宁而出现眼部疾病的患者进行的血清学研究显示，抗核抗体的发生率有所升高。在病情较重的个体中，平滑肌抗体的发生率也略有增加，但这些自身抗体的发生率以及IgG、IgA和IgM水平均在正常范围内。对14例患者眼泪的半定量分析表明，病情较重的患者分泌型IgA缺乏或几乎缺乏，这表明泪腺受到了损害。眼泪中的其他免疫参数正常。
