Koie T, Itoh H, Kawaguchi T, Takahashi N
Department of Urology, Hirosaki University, School of Medicine.
Hinyokika Kiyo. 2000 May;46(5):319-21.
A 75-year-old male presented to our hospital with a complaint of macroscopic hematuria. Laboratory examinations in peripheral blood showed slight anemia and the increase of acute phase reactants (c-reactive protein, immunosuppressive acidic protein, alpha 2-globulin). Abdominal enhanced computerized tomography revealed a huge tumor with calcification at the upper pole of the right kidney. Magnetic resonance imaging (MRI) showed a low intensity mass at the upper portion of the right kidney on T2-weighted sequences. The right radical nephrectomy was performed and the histopathological diagnosis was sarcomatoid renal cell carcinoma because of positive immunohistochemical staining for vimentin and negative for cytokeratin. Because sarcomatoid type has a highly malignant behavior and poor prognosis among renal cell carcinomas, an adjuvant treatment which is effective in controlling the disease is awaited.
一名75岁男性因肉眼血尿前来我院就诊。外周血实验室检查显示轻度贫血以及急性期反应物(C反应蛋白、免疫抑制酸性蛋白、α2球蛋白)升高。腹部增强计算机断层扫描显示右肾上极有一个巨大的钙化肿瘤。磁共振成像(MRI)在T2加权序列上显示右肾上部有一个低强度肿块。实施了右肾根治性切除术,组织病理学诊断为肉瘤样肾细胞癌,因为波形蛋白免疫组化染色阳性而细胞角蛋白染色阴性。由于肉瘤样类型在肾细胞癌中具有高度恶性行为且预后较差,因此期待一种有效控制疾病的辅助治疗方法。