Erofeeva L M, Sapin M R, Grigorenko D E
Laboratory of Functional Anatomy, Russian Academy of Medical Sciences, Moscow.
Morfologiia. 2000;117(1):42-6.
Irradiation of mice with energy-fast carbon ions 4.0 in dose impairs histological structure of thymus on the first day after the challenge. Non differentiated cell forms (blasts and large lymphocytes) and middle lymphocytes were most sensitive to the irradiation. As a result mitotic activity decrease was noted. Reparative process in thymus begins on d 22 after irradiation with carbon ions when stem cells obviously accumulate. At the same time mitotic activity intensifies. Although at distant terms T cells differentiation and formation are inhibited which is reflected in significantly reduced number small lymphocytes in thymus cortex and medulla on d 60 of postirradiation period as compared to that in control.
用剂量为4.0的能量快速碳离子照射小鼠，在照射后第一天会损害胸腺的组织结构。未分化的细胞形式（原始细胞和大淋巴细胞）以及中等大小的淋巴细胞对辐射最为敏感。结果观察到有丝分裂活性降低。在用碳离子照射后第22天，当干细胞明显积累时，胸腺的修复过程开始。与此同时，有丝分裂活性增强。尽管在远期，T细胞的分化和形成受到抑制，这表现为与对照组相比，在照射后第60天胸腺皮质和髓质中小淋巴细胞的数量显著减少。
