[辐射与化学分化诱导剂对小鼠胸腺淋巴细胞存活的影响]
[Effect of irradiation and chemical differentiation inducers on the survival of thymus lymphocytes in mice].
作者信息
Sorokina N I, Soldatenkov V A, Filippovich I V
出版信息
Radiobiologiia. 1985 May-Jun;25(3):304-8.
PMID:4023183
Abstract
Chemical inductors of differentiation were shown to produce a cytotoxic effect on thymus cells. The protein synthesis inhibitors prevented this effect. The toxic action of the inductors was more pronounced in a most radiosensitive thymocyte fraction. A combination of differentiation inductors and ionizing radiation did not produce the additive effect. This was observed after the effect of radiation and substances being not the differentiation inductors but toxic for cells.
摘要
已表明分化化学诱导剂对胸腺细胞产生细胞毒性作用。蛋白质合成抑制剂可阻止这种作用。诱导剂的毒性作用在最具放射敏感性的胸腺细胞亚群中更为明显。分化诱导剂与电离辐射的联合作用并未产生相加效应。在辐射及并非分化诱导剂但对细胞有毒性的物质作用后观察到了这一点。
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