Gavrilova N A, Gruber I M, Filatova T N
Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
Zh Mikrobiol Epidemiol Immunobiol. 2000 Jan-Feb(1):27-30.
In the study of the influence of organic and inorganic sources of iron on the growth of 5 C. diphtheriae clinical isolates bacterial growth was found to depended on the nature of the source of iron and its concentration. Differences between the strains in the level of growth, observed when ferric sulfate was used as the only source of iron in the medium, were established. Quantitative differences in the concentrations of inorganic and organic sources of iron, necessary for growth, were determined. The influence of three chemical chelators on the growth of C. diphtheriae under the conditions of iron deficiency in the culture medium was studied. The results of the study are indicative of the possibility of the differentiation of C. diphtheriae isolated according to the level of iron consumption.
在研究有机和无机铁源对5株白喉棒状杆菌临床分离株生长的影响时,发现细菌生长取决于铁源的性质及其浓度。当硫酸铁作为培养基中唯一的铁源时,观察到各菌株在生长水平上存在差异。确定了生长所需的无机和有机铁源浓度的定量差异。研究了三种化学螯合剂在培养基缺铁条件下对白喉棒状杆菌生长的影响。研究结果表明,根据铁消耗水平对白喉棒状杆菌分离株进行区分是可能的。