来自哥伦比亚白种人与梅斯蒂索人样本中6个短串联重复序列位点的群体数据。
Population data on 6 short tandem repeat loci in a sample of Caucasian-Mestizos from Colombia.
作者信息
Yunis J J, García O, Uriarte I, Yunis E J
机构信息
Instituto de Genética, Universidad Nacional de Colombia, Santa Fé de Bogotá, DC.
出版信息
Int J Legal Med. 2000;113(3):175-8. doi: 10.1007/s004140050293.
Blood samples from 409-452 unrelated Colombian Caucasian-Mestizo individuals were amplified and typed for six short tandem repeat (STR) markers (HUMF13A01, HUMFES/FPS, HUMVWA, HUMCSF1PO, HUMTPOX, HUMTH01). The allele frequencies, genotype frequencies, heterozygosity, mean paternity exclusion chance, polymorphism information content, discrimination power, assumption of independence within and between loci and Hardy Weinberg equilibrium were determined. The results demonstrate that all markers conform to Hardy-Weinberg equilibrium expectations. In addition, the results demonstrate the assumption of independence within and between the loci analysed. The mean exclusion chance (MEC) was 0.9851 for all six STR loci analysed and the discrimination power (DP) was 0.9999973. Therefore, this Colombian population database can be used in identity testing to estimate the frequency of a multiple PCR-based locus DNA profile in forensic cases as well as in paternity testing.
对409至452名无血缘关系的哥伦比亚白种-梅斯蒂索人个体的血样进行扩增，并对六个短串联重复序列（STR）标记（HUMF13A01、HUMFES/FPS、HUMVWA、HUMCSF1PO、HUMTPOX、HUMTH01）进行分型。确定了等位基因频率、基因型频率、杂合性、平均父权排除率、多态性信息含量、鉴别力、基因座内部和之间的独立性假设以及哈迪-温伯格平衡。结果表明，所有标记均符合哈迪-温伯格平衡预期。此外，结果证明了所分析基因座内部和之间的独立性假设。对所分析的所有六个STR基因座而言，平均排除率（MEC）为0.9851，鉴别力（DP）为0.9999973。因此，这个哥伦比亚人群数据库可用于身份鉴定测试，以估计法医案件中基于多重PCR的基因座DNA图谱的频率以及亲子鉴定。
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