Blomhoff S, Spetalen S, Jacobsen M B, Vatn M, Malt U F
Department of Psychosomatic and Behavioural Medicine, National Hospital, Oslo, Norway.
Dig Dis Sci. 2000 Jun;45(6):1160-5. doi: 10.1023/a:1005502119461.
The intestinal reactivity to emotional experiences is poorly understood. We therefore compared healthy controls with nonpsychiatric irritable bowel syndrome (IBS) patients and IBS patients with comorbid phobic anxiety disorders with respect to rectal wall reactivity during exposure to everyday words with emotional content. We found that 70.3% of the subjects responded either with increased or decreased rectal tone during exposure to anger words, 75.0% when exposed to sadness words, and 76.6% when exposed to anxiety words. We also investigated event-related potentials in the brain to the same stimuli. We observed significant group differences in the frontal brain to sadness (P < 0.001) and anxiety (P = 0.013) distracter words, and threshold significant group difference to anger (P = 0.053) distracter words. Rectal wall reactivity during the word series significantly predicted frontal amplitude to the same word series, indicating a close interaction among mind, brain, and gut.
人们对肠道对情绪体验的反应性了解甚少。因此，我们比较了健康对照组、非精神性肠易激综合征（IBS）患者以及伴有共病恐惧性焦虑障碍的IBS患者在接触带有情感内容的日常词汇时直肠壁的反应性。我们发现，70.3%的受试者在接触愤怒词汇时直肠张力增加或降低，接触悲伤词汇时这一比例为75.0%，接触焦虑词汇时为76.6%。我们还研究了大脑对相同刺激的事件相关电位。我们观察到，额叶大脑对悲伤（P < 0.001）和焦虑（P = 0.013）干扰词存在显著的组间差异，对愤怒（P = 0.053）干扰词存在阈值显著的组间差异。词汇系列过程中的直肠壁反应性显著预测了对相同词汇系列的额叶振幅，表明心理、大脑和肠道之间存在密切的相互作用。
