Whitehead W E, Crowell M D, Davidoff A L, Palsson O S, Schuster M M
Division of Digestive Diseases and Nutrition, University of North Carolina at Chapel Hill, 27599-7080, USA.
Dig Dis Sci. 1997 Apr;42(4):796-804. doi: 10.1023/a:1018820315549.
The aims of this study were to determine whether increased pain sensitivity in patients with irritable bowel is due to physiological differences in perceptual sensitivity or psychological influences on perception, and whether prior sexual abuse accounts for increased pain sensitivity. Seventeen sexually abused and 15 nonabused women with irritable bowel were compared to 13 sexually abused and 14 nonabused women without irritable bowel. Among the nonabused subjects, the volume of rectal distension that produced moderate pain was lower in IBS patients than in controls, replicating earlier studies, but these thresholds were correlated with psychological measures of anxiety and somatization. The ability to discriminate between painful distensions (perceptual sensitivity) was not different between groups. Sexual abuse was not associated with lower pain thresholds. Thus, differences in pain sensitivity appear to be due to psychological influences on perception, but a history of sexual abuse does not contribute significantly to this pain sensitivity.
本研究的目的是确定肠易激综合征患者疼痛敏感性增加是由于感知敏感性的生理差异还是心理对感知的影响，以及既往性虐待是否导致疼痛敏感性增加。将17名遭受性虐待和15名未遭受性虐待的肠易激综合征女性与13名遭受性虐待和14名未遭受性虐待的无肠易激综合征女性进行比较。在未遭受性虐待的受试者中，与早期研究结果一致，肠易激综合征患者产生中度疼痛的直肠扩张量低于对照组，但这些阈值与焦虑和躯体化的心理测量指标相关。两组之间区分疼痛扩张的能力（感知敏感性）没有差异。性虐待与较低的疼痛阈值无关。因此，疼痛敏感性的差异似乎是由于心理对感知的影响，但性虐待史对这种疼痛敏感性没有显著影响。
