Mcewan N A
Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden, Glasgow, G61 1QH, UK.
Res Vet Sci. 2000 Jun;68(3):279-83. doi: 10.1053/rvsc.2000.0378.
The adherence of Staphylococcus intermedius to canine keratinocytes in normal dogs was compared to that in dogs suffering from atopic dermatitis, primary seborrhoea and bacterial pyoderma. Statistically significant greater adherence by S. intermedius to keratinocytes occurred in atopic dogs and dogs suffering from pyoderma when compared with the normal group (P < 0.01) and dogs suffering from primary seborrhoea (P < 0.05). This is similar to the results of a study of human atopic dermatitis by Cole and Silverberg (1986) who demonstrated increased adherence by S. aureus to keratinocytes from atopic dermatitis patients when compared with adherence to keratinocytes in a variety of non-atopic dermatoses. This increased adherence by pathogenic staphylococci to keratinocytes may in part explain the high incidence of staphylococcal pyoderma seen in both canine and human patients suffering from atopic dermatitis.
将中间葡萄球菌在正常犬和患有特应性皮炎、原发性皮脂溢及细菌性脓皮病的犬中对犬角质形成细胞的黏附情况进行了比较。与正常组（P < 0.01）及患有原发性皮脂溢的犬（P < 0.05）相比，中间葡萄球菌对特应性犬和患有脓皮病的犬的角质形成细胞的黏附在统计学上显著更高。这与Cole和Silverberg（1986年）对人类特应性皮炎的一项研究结果相似，他们证明与金黄色葡萄球菌对多种非特应性皮炎皮肤病的角质形成细胞的黏附相比，其对特应性皮炎患者角质形成细胞的黏附增加。致病性葡萄球菌对角质形成细胞黏附的增加可能部分解释了在患有特应性皮炎的犬类和人类患者中所见的葡萄球菌性脓皮病的高发病率。
