Venkatesh B, Gilligan P, Brenner S
Institute of Molecular and Cell Biology, National University of Singapore, 30 Medical Drive, 117609, Singapore.
FEBS Lett. 2000 Jun 30;476(1-2):3-7. doi: 10.1016/s0014-5793(00)01659-8.
At 400 Mb, the Japanese pufferfish, Fugu rubripes, has the smallest vertebrate genome but has a similar gene repertoire to other vertebrates. Its genes are densely packed with short intergenic and intronic sequences devoid of repetitive elements. It likely has a mutational bias towards DNA elimination and is probably close to a 'minimal' vertebrate genome. As such it is a useful reference genome for gene discovery and gene validation in other vertebrates. Its usefulness in the discovery of conserved regulatory elements has already been demonstrated. The Fugu genome sequence is a good complement to genetic studies in other vertebrates.
日本河豚红鳍东方鲀的基因组大小为400兆碱基对，是脊椎动物中最小的，但基因库与其他脊椎动物相似。其基因紧密排列，基因间和内含子序列短，且无重复元件。它可能存在偏向于DNA消除的突变倾向，可能接近“最小”的脊椎动物基因组。因此，它是其他脊椎动物基因发现和基因验证的有用参考基因组。其在保守调控元件发现中的作用已得到证实。河豚基因组序列是其他脊椎动物遗传学研究的良好补充。
