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细胞内细菌病原体对宿主细胞凋亡的调控。

The modulation of host cell apoptosis by intracellular bacterial pathogens.

作者信息

Gao L Y, Kwaik Y A

机构信息

Program in Microbial Pathogenesis and Host Defense, University of California at San Fransisco, HSE-201, Box 0654, 513 Parnassus Avenue, San Fransisco, CA 94143-0654, USA.

出版信息

Trends Microbiol. 2000 Jul;8(7):306-13. doi: 10.1016/s0966-842x(00)01784-4.

DOI:10.1016/s0966-842x(00)01784-4
PMID:10878765
Abstract

Recent years have witnessed significant advances in unraveling the elegant mechanisms by which intracellular bacterial pathogens induce and/or block apoptosis, which can influence disease progression. This intriguing aspect of the host-pathogen interaction adds another fascinating dimension to our understanding of the exploitation of host cell biology by intracellular bacterial pathogens.

摘要

近年来,在揭示细胞内细菌病原体诱导和/或阻断细胞凋亡的精妙机制方面取得了重大进展,而这些机制会影响疾病进展。宿主与病原体相互作用的这一有趣方面,为我们理解细胞内细菌病原体对宿主细胞生物学的利用增添了另一个迷人的维度。

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