Musk A W, Robertson P W
Aust N Z J Med. 1976 Aug;6(4):284-7. doi: 10.1111/imj.1976.6.4.284.
Serum from 224 males investigated in a prospective study of respiratory disorders in a recently established asbestos industry has been estimated for alpha-1 antitrypsin (AAT) concentration by single radial immunodiffusion. Mean AAT concentration was 213-4 mg/dl). No subject with a markedly reduced level was found. A comprehensive range of lung function tests sensitive to changes anticipated in emphysema at a preclinical stage, included measurements of diffusing capacity and pulmonary elastic recoil. The 26 subjects with AAT concentration less than 150 mg/dl, were regarded as likely to comprise a majority of genotypes MZ and SS, and the 19 subjects with AAT concentration greater than 300 mg/dl were considered to comprise mainly MM. No difference in pulmonary function could be demonstrated between these two groups. Evidence of diminished pulmonary elastic recoil was found in nine smoking subjects whose AAT concentrations were normal and also in one young non-smoking subject with moderately severe asthma, whose AAT concentration was 140 mg/dl. It is concluded that in a male working population, evidence of diminished pulmonary elastic recoil is not a function of AAT concentration.
在一个新近建立的石棉行业对224名男性进行的呼吸系统疾病前瞻性研究中，通过单向放射免疫扩散法对血清中的α-1抗胰蛋白酶（AAT）浓度进行了测定。AAT平均浓度为213.4mg/dl。未发现有明显降低水平的受试者。一系列对临床前期肺气肿预期变化敏感的肺功能测试，包括弥散功能和肺弹性回缩力的测量。26名AAT浓度低于150mg/dl的受试者，被认为可能大多数为MZ和SS基因型，19名AAT浓度高于300mg/dl的受试者被认为主要为MM基因型。这两组之间在肺功能上未显示出差异。在9名AAT浓度正常的吸烟受试者以及1名AAT浓度为140mg/dl的中度重度哮喘年轻非吸烟受试者中发现了肺弹性回缩力减弱的证据。得出的结论是，在男性劳动人群中，肺弹性回缩力减弱的证据并非AAT浓度的作用。
